Paper published: Poly(vinyl alcohol) Potentiating an Inert D-Amino Acid-Based Drug for Boron Neutron Capture Therapy

The paper titled “Poly(vinyl alcohol) potentiating an inert D-amino acid-based drug for boron neutron capture therapy” of the Journal of Controlled Release describes the combination of D-BPA (4-borono phenylalanine) and poly(vinyl alcohol) (PVA) that reached prolonged intracellular retention of boron in cancer cells. For this study Stella Pharma provided the 10B-riched L-/D-BPA. In a subcutaneous tumor model, the system designed in this study accomplished surprisingly higher tumor-selective accumulation of 10B compound than conventional approaches and induced drastic BNCT effects.

The paper can be found following this link